Journal article
Comparative studies of Campylobacter jejuni genomic diversity reveal the importance of core and dispensable genes in the biology of this enigmatic food-borne pathogen
Current opinion in biotechnology, Vol.20(2), pp.158-165
04/2009
Handle:
https://hdl.handle.net/2376/102610
PMCID: PMC2769087
PMID: 19346123
Abstract
MLST, DNA microarrays, and genome sequencing has allowed for a greater understanding of the metabolic capacity and epidemiology of Campylobacter jejuni. While strain-specific genes may provide an isolate a selective advantage in environments and contribute to the organism's pathogenicity, recent work indicates that C. jejuni pathogenicity is dictated by variations in the nucleotide sequence of core genes. Challenges facing C. jejuni researchers include determining (a) the degree to which genomic diversity enables this bacterium to persist in particular environments; (b) if C. jejuni virulence and disease severity can be predicted on the basis of genotype; (c) the set of core and variable genes whose products contribute to virulence; and (d) the genes in which nucleotide changes can affect a strain's pathogenicity.
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Details
- Title
- Comparative studies of Campylobacter jejuni genomic diversity reveal the importance of core and dispensable genes in the biology of this enigmatic food-borne pathogen
- Creators
- Tri Duong - School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USAMichael E Konkel
- Publication Details
- Current opinion in biotechnology, Vol.20(2), pp.158-165
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- England
- Grant note
- N01 AI030055 / NIAID NIH HHS N01AI30055 / NIAID NIH HHS
- Identifiers
- 99900546692601842
- Language
- English
- Resource Type
- Journal article