Journal article
Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus
International journal of biological sciences, Vol.4(2), pp.96-102
01/01/2008
Handle:
https://hdl.handle.net/2376/110821
PMCID: PMC2359900
PMID: 18463714
Abstract
Several reports have shown that urotensin 2 (
UTS2
) and its receptor (
UTS2R
) are involved in glucose metabolism and insulin resistance, which lead to development of type 2 diabetes mellitus (T2DM) in humans. In the present study, we annotated both bovine
UTS2
and
UTS2R
genes and identified 5 single nucleotide polymorphisms (SNPs) for the former gene and 14 mutations for the latter gene. Four mutations were genotyped on a Wagyu x Limousin reference population, including 6 F
1
bulls, 113 F
1
dams and ~250 F
2
progeny. Among 12 phenotypes related to fat deposition and fatty acid composition, we observed that the
UTS2
gene was significantly associated with the amount of skeletal saturated fatty acids, while its receptor (
UTS2R
) gene had significant effects on amounts of saturated and monounsaturated fatty acids, Δ
9
desaturase activity for converting 16:0 into 16:1, muscle fat (marbling) score and
Longissimus Dorsi
muscle area. However, in this population, these markers were not associated with subcutaneous fat depth or percent kidney, pelvic and heart fat. We also found that mutations in the promoter regions altered the promoter activities in both genes and coding SNPs might affect the mRNA stability in the
UTS2R
gene. Overall, our present study provides the first evidence that both
UTS2
and
UTS2R
genes regulate skeletal muscle fat accumulation and fatty acid metabolism, thus indicating their potential pathological functions related to obesity and T2DM in humans.
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Details
- Title
- Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus
- Creators
- Zhihua Jiang - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164–6351, USAJennifer J Michal - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164–6351, USADavid J Tobey - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164–6351, USAZeping Wang - 2. School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4660, USAMichael D MacNeil - 3. USDA Agricultural Research Service Fort Keogh Livestock, Range Research Laboratory, Miles City, MT 59301, USANancy S Magnuson - 2. School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4660, USA
- Publication Details
- International journal of biological sciences, Vol.4(2), pp.96-102
- Academic Unit
- Animal Sciences, Department of; Molecular Biosciences, School of
- Publisher
- Ivyspring International Publisher; Sydney
- Identifiers
- 99900547367301842
- Language
- English
- Resource Type
- Journal article