Journal article
Comparison of angiotensin metabolism by brain membranes from SHR and WKY rats
Brain research, Vol.529(1), pp.320-323
1990
Handle:
https://hdl.handle.net/2376/109241
PMID: 2282500
Abstract
The ability of membrane-associated peptidases from the brains of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats to metabolize iodinated angiotensin (
125I-Ang II) and
125I-Ang III was compared.
125I-Ang II was metabolized to
125I-Ang III and other fragments exclusively by membrane-associated peptidases. In contrast to
125I-Ang III which was effectively degradated by both membrane-associated and residual cytosolic peptidases,
125I-Ang II was unaltered by contanimating cytosolic enzymes. The ability of SHR-derived membranes to metabolize
125I-Ang II and produce
125I-Ang III was enhanced when compared to membranes from WKY rats. No difference was observed in the ability of membrane or cytosolic enzymes from SHR and WKY rats to degrade
125I-Ang III. These data are consistent with an increased availability of Ang III in the brains of SHRs.
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Details
- Title
- Comparison of angiotensin metabolism by brain membranes from SHR and WKY rats
- Creators
- Vickie I Cook - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520 U.S.AJohn W Wright - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520 U.S.AShonna A Wright - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520 U.S.AJoseph W Harding - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520 U.S.A
- Publication Details
- Brain research, Vol.529(1), pp.320-323
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547022501842
- Language
- English
- Resource Type
- Journal article