Journal article
Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study
Journal of feline medicine and surgery, Vol.21(10), pp.951-958
10/2019
Handle:
https://hdl.handle.net/2376/107650
PMID: 30427274
Abstract
Objectives This pilot study sought to assess the metabolism of Plavix (Bristol-Myers Squibb/Sanofi) and generic clopidogrel in cats, using a novel assay for the measurement of clopidogrel, clopidogrel carboxylic acid (CCA) and clopidogrel active metabolite (CAM-D). Methods This was a prospective, randomized, double-blind study. Four healthy, skeletally mature cats were enrolled into the study. There were two treatment phases during which cats received either Plavix or generic clopidogrel at a dosage of 18.75 mg PO q24h for 7 days with a 2 week washout between phases. During each phase, plasma concentrations of parent drug and active and inactive metabolites were measured along with impedance platelet aggregometry in response to adenosine diphosphate (ADP). Results The ratio of CAM-D between generic clopidogrel and Plavix was 0.83 (equivalence reference 1.00, 90% confidence interval 0.80–1.25). Inhibition of ADP-induced platelet aggregation was variable, with two cats classified as non-responders in both treatment phases. The concentrations of CAM-D were not predictive of aggregometry-based responsiveness to either formulation of clopidogrel. Conclusions and relevance This is the first study comparing Plavix and generic clopidogrel in cats. Administration of the generic formulation resulted in comparable plasma concentrations of clopidogrel active metabolite when compared with Plavix.
Metrics
9 Record Views
Details
- Title
- Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study
- Creators
- Mays Malkawi - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAndrew D Woolcock - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAPamela M Lee - Program in Individualized Medicine (PriMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USAMichael H Court - Program in Individualized Medicine (PriMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USAGeorge E Moore - Department of Veterinary Administration, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USADaniel F Hogan - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA
- Publication Details
- Journal of feline medicine and surgery, Vol.21(10), pp.951-958
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Identifiers
- 99900547193301842
- Language
- English
- Resource Type
- Journal article