Journal article
Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis)
2007
Handle:
https://hdl.handle.net/2376/106908
Abstract
The rhadinovirus Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance in vitro. Amino acid identity between
the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in
the G/E-rich repetitive central region of the ORF.
Metrics
7 Record Views
Details
- Title
- Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis)
- Creators
- N S TausD R HerndonD L TraulJ P StewartM AckermannH LiD P KnowlesG S LewisK A Brayton
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Society for General Microbiology
- Identifiers
- 99900546979001842
- Language
- English
- Resource Type
- Journal article