Journal article
Composition, Roles, and Regulation of Cullin-Based Ubiquitin E3 Ligases
The arabidopsis book, Vol.12, pp.e0175-e0175
2014
Handle:
https://hdl.handle.net/2376/110804
PMCID: PMC4262284
PMID: 25505853
Abstract
Due to their sessile nature, plants depend on flexible regulatory systems that allow them to adequately regulate developmental and physiological processes in context with environmental cues. The ubiquitin proteasome pathway, which targets a great number of proteins for degradation, is cellular tool that provides the necessary flexibility to accomplish this task. Ubiquitin E3 ligases provide the needed specificity to the pathway by selectively binding to particular substrates and facilitating their ubiquitylation. The largest group of E3 ligases known in plants is represented by CULLIN-REALLY INTERESTING NEW GENE (RING) E3 ligases (CRLs). In recent years, a great amount of knowledge has been generated to reveal the critical roles of these enzymes across all aspects of plant life. This review provides an overview of the different classes of CRLs in plants, their specific complex compositions, the variety of biological processes they control, and the regulatory steps that can affect their activities.
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Details
- Title
- Composition, Roles, and Regulation of Cullin-Based Ubiquitin E3 Ligases
- Creators
- Christina M Choi - Washington State University, Pullman, WashingtonWilliam M Gray - University of Minnesota, St Paul, MinnesotaSutton Mooney - Washington State University, Pullman, WashingtonHanjo Hellmann - Washington State University, Pullman, Washington
- Publication Details
- The arabidopsis book, Vol.12, pp.e0175-e0175
- Academic Unit
- Biological Sciences, School of
- Publisher
- American Society of Plant Biologists
- Identifiers
- 99900546906901842
- Language
- English
- Resource Type
- Journal article