Journal article
Confocal microscopy for modeling electron microbeam irradiation of skin
Radiation and environmental biophysics, Vol.50(3), pp.365-369
08/2011
Handle:
https://hdl.handle.net/2376/107680
PMID: 21604000
Abstract
For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tissues. Employing high-resolution confocal microscopy, we have determined the spatial distribution, size, and shape of epidermal keratinocyte nuclei for the full-thickness EpiDerm™ skin model (MatTek, Ashland, VA). Application of these data to calculate the microdosimetry and microdistribution of energy deposition by an electron microbeam is discussed.
Metrics
21 Record Views
Details
- Title
- Confocal microscopy for modeling electron microbeam irradiation of skin
- Creators
- John Miller - School of Electrical Engineering and Computer Science Washington State University Tri-Cities 2710 University Drive Richland WA 99354 USAWilliam Chrisler - Cell Biology and Biochemistry Pacific Northwest National Laboratory Richland WA 99354 USAXihai Wang - Biological Monitoring and Modeling Pacific Northwest National Laboratory Richland WA 99354 USAMarianne Sowa - Cell Biology and Biochemistry Pacific Northwest National Laboratory Richland WA 99354 USA
- Publication Details
- Radiation and environmental biophysics, Vol.50(3), pp.365-369
- Academic Unit
- Engineering and Applied Sciences (TRIC), School of
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Identifiers
- 99900547480101842
- Language
- English
- Resource Type
- Journal article