Journal article
Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis
Journal of virology, Vol.87(24), pp.13922-13926
12/2013
Handle:
https://hdl.handle.net/2376/101590
PMCID: PMC3838226
PMID: 24109213
Abstract
Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the required HSV glycoproteins, gB, gD, and gH-gL, may be sufficient for entry regardless of entry route taken. This may be distinct from entry mechanisms employed by other human herpesviruses.
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Details
- Title
- Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis
- Creators
- Tri Komala Sari - Department of Veterinary Microbiology and Pathology, Washington State UniversitySuzanne M Pritchard - Department of Veterinary Microbiology and Pathology, Washington State UniversityCristina W Cunha - Department of Veterinary Microbiology and Pathology, Washington State UniversityGeorge A Wudiri - Department of Veterinary Microbiology and Pathology, Washington State UniversityElizabeth I Laws - Department of Veterinary Microbiology and Pathology, Washington State UniversityHector C Aguilar - Paul G. Allen School for Global Animal Health, Washington State UniversityNaomi S Taus - Animal Disease Research Unit, USDA-Agricultural Research ServiceAnthony V Nicola - Department of Veterinary Microbiology and Pathology, Washington State University
- Publication Details
- Journal of virology, Vol.87(24), pp.13922-13926
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- Identifiers
- 99900546534701842
- Language
- English
- Resource Type
- Journal article