Journal article
Control of skin cancer by the circadian rhythm
Proceedings of the National Academy of Sciences - PNAS, Vol.108(46), pp.18790-18795
11/15/2011
Handle:
https://hdl.handle.net/2376/103139
PMCID: PMC3219110
PMID: 22025708
Abstract
Skin cancer is the most common form of cancer in the United States. The main cause of this cancer is DNA damage induced by the UV component of sunlight. In humans and mice, UV damage is removed by the nucleotide excision repair system. Here, we report that a rate-limiting subunit of excision repair, the xeroderma pigmentosum group A (XPA) protein, and the excision repair rate exhibit daily rhythmicity in mouse skin, with a minimum in the morning and a maximum in the afternoon/evening. In parallel with the rhythmicity of repair rate, we find that mice exposed to UV radiation (UVR) at 4:00 AM display a decreased latency and about a fivefold increased multiplicity of skin cancer (invasive squamous cell carcinoma) than mice exposed to UVR at 4:00 PM. We conclude that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans.
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Details
- Title
- Control of skin cancer by the circadian rhythm
- Creators
- Shobhan Gaddameedhi - Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USAChristopher P SelbyWilliam K KaufmannRobert C SmartAziz Sancar
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.108(46), pp.18790-18795
- Academic Unit
- UNKNOWN
- Publisher
- United States
- Grant note
- GM31082 / NIGMS NIH HHS P30 ES010126 / NIEHS NIH HHS R01 GM031082 / NIGMS NIH HHS R37 GM031082 / NIGMS NIH HHS ES014635 / NIEHS NIH HHS R01 GM032833 / NIGMS NIH HHS GM32833 / NIGMS NIH HHS P01 ES014635 / NIEHS NIH HHS
- Identifiers
- 99900546675801842
- Language
- English
- Resource Type
- Journal article