Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide

Elisabeth Day Henry; Yusuke Ohgami; Shuang Li; Eunhee Chung; Raymond M Quock

doi:10.1016/j.pbb.2005.05.013

Back

Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide

Journal article

Peer reviewed

Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide

Elisabeth Day Henry, Yusuke Ohgami, Shuang Li, Eunhee Chung and Raymond M Quock

Pharmacology, biochemistry and behavior, Vol.81(4), pp.764-768

2005

DOI: https://doi.org/10.1016/j.pbb.2005.05.013

Handle:

https://hdl.handle.net/2376/110322

PMID: 15993935

Abstract

Antinociception

Nitric oxide synthase

Nitrous oxide

Mice

Short-term selective breeding

Inhibition of nitric oxide synthase (NOS) antagonizes nitrous oxide (N 2O)-induced antinociception in mice. This study was conducted to compare brain NOS activity in high responding C57BL/6 mice, low responding DBA/2 mice and S 5 mice selectively bred for low responsiveness to N 2O. Exposure to 70% N 2O suppressed acetic acid-induced abdominal constrictions in C57BL/6 mice but not DBA/2 or S 5 mice. N 2O exposure also elevated NOS activity in brains of C57BL/6 mice but not DBA/2 or S 5 mice. The absence of these effects in DBA/2 or S 5 mice is further support for the hypothesis that nitric oxide (NO) may play a critical role in N 2O-induced antinociception in mice.

Metrics

9 Record Views

Details

Title: Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide
Creators: Elisabeth Day Henry - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
Yusuke Ohgami - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
Shuang Li - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
Eunhee Chung - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
Raymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
Publication Details: Pharmacology, biochemistry and behavior, Vol.81(4), pp.764-768
Academic Unit: Psychology, Department of
Publisher: Elsevier Inc
Identifiers: 99900547308401842
Language: English
Resource Type: Journal article

Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide

Related links

Abstract

Metrics

Details