Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice

Jennifer R Gruhn; Nasser Al-Asmar; Rachael Fasnacht; Heather Maylor-Hagen; Vanessa Peinado; Carmen Rubio; Karl W Broman; Patricia A Hunt; Terry Hassold

doi:10.1016/j.ajhg.2015.11.019

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Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice

Journal article

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Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice

Jennifer R Gruhn, Nasser Al-Asmar, Rachael Fasnacht, Heather Maylor-Hagen, Vanessa Peinado, Carmen Rubio, Karl W Broman, Patricia A Hunt and Terry Hassold

American journal of human genetics, Vol.98(1), pp.102-115

01/07/2016

DOI: https://doi.org/10.1016/j.ajhg.2015.11.019

Handle:

https://hdl.handle.net/2376/106980

PMCID: PMC4716685

PMID: 26749305

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Abstract

Meiosis - genetics

Animals

Recombination, Genetic

Synapses - physiology

Humans

Female

Male

Mice

Meiotic recombination is initiated by programmed double strand breaks (DSBs), only a small subset of which are resolved into crossovers (COs). The mechanism determining the location of these COs is not well understood. Studies in plants, fungi, and insects indicate that the same genomic regions are involved in synaptic initiation and COs, suggesting that early homolog alignment is correlated with the eventual resolution of DSBs as COs. It is generally assumed that this relationship extends to mammals, but little effort has been made to test this idea. Accordingly, we conducted an analysis of synaptic initiation sites (SISs) and COs in human and mouse spermatocytes and oocytes. In contrast to our expectation, we observed remarkable sex- and species-specific differences, including pronounced differences between human males and females in both the number and chromosomal location of SISs. Further, the combined data from our studies in mice and humans suggest that the relationship between SISs and COs in mammals is a complex one that is not dictated by the sites of synaptic initiation as reported in other organisms, although it is clearly influenced by them.

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Title: Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice
Creators: Jennifer R Gruhn - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Nasser Al-Asmar - Preimplantation Genetic Diagnosis Unit, Igenomix, Miami, FL 33126, USA
Rachael Fasnacht - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Heather Maylor-Hagen - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Vanessa Peinado - Preimplantation Genetic Diagnosis Unit, Igenomix, Paterna, Valencia 46980, Spain
Carmen Rubio - Preimplantation Genetic Diagnosis Unit, Igenomix, Paterna, Valencia 46980, Spain
Karl W Broman - Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA
Patricia A Hunt - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Terry Hassold - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA. Electronic address: terryhassold@vetmed.wsu.edu
Publication Details: American journal of human genetics, Vol.98(1), pp.102-115
Academic Unit: Molecular Biosciences, School of
Publisher: United States
Grant note: R01 ES013527 / NIEHS NIH HHS R37 HD21341 / NICHD NIH HHS R01 ES13527 / NIEHS NIH HHS R37 HD021341 / NICHD NIH HHS
Identifiers: 99900546750201842
Language: English
Resource Type: Journal article