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Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region
Journal article

Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region

Simon J Shaw, Hugo G Menzella, David C Myles, Ming Xian and Amos B Smith, 3rd
Organic & biomolecular chemistry, Vol.5(17), pp.2753-2755
09/07/2007
DOI: https://doi.org/10.1039/b708884c
Handle:
https://hdl.handle.net/2376/113856
PMID: 17700839

Abstract

Humans Coumarins - chemistry Carbamates - chemistry Lactones - toxicity Alkanes - toxicity Alkanes - chemical synthesis Biological Products - chemistry Carbamates - chemical synthesis Lactones - chemical synthesis Pyrones - chemistry Coumarins - chemical synthesis Cell Line, Tumor Biological Products - toxicity Cell Proliferation - drug effects Molecular Structure Pyrones - chemical synthesis Pyrones - toxicity Alkanes - chemistry Coumarins - toxicity Carbamates - toxicity Lactones - chemistry
Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.

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