Journal article
Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation
Chemical communications (Cambridge, England), Vol.49(83), pp.9618-9620
10/25/2013
Handle:
https://hdl.handle.net/2376/111293
PMCID: PMC4399865
PMID: 24022092
Abstract
We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.
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Details
- Title
- Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation
- Creators
- Janine K Tom - Department of Chemistry, University of California Irvine, Irvine, CA 92697, USA. aesserka@uci.eduRock J ManciniAaron P Esser-Kahn
- Publication Details
- Chemical communications (Cambridge, England), Vol.49(83), pp.9618-9620
- Academic Unit
- Department of Chemistry
- Publisher
- England
- Grant note
- DP2 AI112194 / NIAID NIH HHS P30 CA062203 / NCI NIH HHS
- Identifiers
- 99900547709501842
- Language
- English
- Resource Type
- Journal article