Covalently coupled immunostimulant heterodimers

Rock J Mancini; Janine K Tom; Aaron P Esser-Kahn

doi:10.1002/anie.201306551

Back

Covalently coupled immunostimulant heterodimers

Journal article

Open access

Peer reviewed

Covalently coupled immunostimulant heterodimers

Rock J Mancini, Janine K Tom and Aaron P Esser-Kahn

Angewandte Chemie (International ed.), Vol.53(1), pp.189-192

01/03/2014

DOI: https://doi.org/10.1002/anie.201306551

Handle:

https://hdl.handle.net/2376/112536

PMCID: PMC4049977

PMID: 24259411

Files and links (1)

url

https://doi.org/10.1002/anie.201306551View

Published (Version of record) Open

Abstract

Polymers - chemistry

Adjuvants, Immunologic - chemistry

Phosphorylation

Signal Transduction

We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.

Metrics

18 Record Views

See more details

Details

Title: Covalently coupled immunostimulant heterodimers
Creators: Rock J Mancini - Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA)
Janine K Tom
Aaron P Esser-Kahn
Publication Details: Angewandte Chemie (International ed.), Vol.53(1), pp.189-192
Academic Unit: Department of Chemistry
Publisher: Germany
Grant note: DP2 AI112194 / NIAID NIH HHS P30 CA062203 / NCI NIH HHS
Identifiers: 99900547505201842
Language: English
Resource Type: Journal article