Journal article
Covariation of synaptonemal complex length and mammalian meiotic exchange rates
Science (American Association for the Advancement of Science), Vol.296(5576), pp.2222-2225
06/21/2002
Handle:
https://hdl.handle.net/2376/116058
PMID: 12052900
Abstract
Analysis of recombination between loci (linkage analysis) has been a cornerstone of human genetic research, enabling investigators to localize and, ultimately, identify genetic loci. However, despite these efforts little is known about patterns of meiotic exchange in human germ cells or the mechanisms that control these patterns. Using recently developed immunofluorescence methodology to examine exchanges in human spermatocytes, we have identified remarkable variation in the rate of recombination within and among individuals. Subsequent analyses indicate that, in humans and mice, this variation is linked to differences in the length of the synaptonemal complex. Thus, at least in mammals, a physical structure, the synaptonemal complex, reflects genetic rather than physical distance.
Metrics
18 Record Views
Details
- Title
- Covariation of synaptonemal complex length and mammalian meiotic exchange rates
- Creators
- Audrey Lynn - Department of Genetics, Case Western Reserve University, Cleveland, OH, USAKara E KoehlerLuAnn JudisErnest R ChanJonathan P CherryStuart SchwartzAllen SeftelPatricia A HuntTerry J Hassold
- Publication Details
- Science (American Association for the Advancement of Science), Vol.296(5576), pp.2222-2225
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- United States
- Grant note
- HD37502 / NICHD NIH HHS HD07518 / NICHD NIH HHS HD21341 / NICHD NIH HHS
- Identifiers
- 99900548046401842
- Language
- English
- Resource Type
- Journal article