Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue

William C Davis; Sally A Madsen-Bouterse

doi:10.1016/j.vetimm.2011.12.005

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Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue

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Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue

William C Davis and Sally A Madsen-Bouterse

Veterinary immunology and immunopathology, Vol.145(1-2), pp.1-6

01/15/2012

DOI: https://doi.org/10.1016/j.vetimm.2011.12.005

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https://hdl.handle.net/2376/115962

PMCID: PMC3273645

PMID: 22209202

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Abstract

Cattle Diseases - microbiology

Paratuberculosis - microbiology

Intestines - pathology

Mycobacterium avium subsp. paratuberculosis - immunology

Humans

Paratuberculosis - immunology

Cattle Diseases - pathology

Crohn Disease - immunology

Cattle Diseases - immunology

Intestines - immunology

Paratuberculosis - pathology

Animals

Intestines - microbiology

Cattle

Crohn Disease - pathology

Crohn Disease - microbiology

Crohn Disease - etiology

Disease Models, Animal

The initial suggestion that Mycobacterium avium subsp. paratuberculosis (Map) might be involved in the pathogenesis of Crohn's disease (CD) was based on the apparent similarity of lesions in the intestine of patients with CD with those present in cattle infected with Map, the etiological agent of Johne's disease (JD). Recent investigations have now revealed the presence of Map or Map DNA in blood or lesions from adults and children with CD. Of special interest, Map has also been found in patients with other diseases as well as healthy subjects. The latter observations indicate all humans are susceptible to infection with Map and that, like with other mycobacterial pathogens such as Mycobacterium tuberculosis, infection does not invariably lead to development of clinical disease but rather development of a persistent latent stage of infection where an immune response controls but does not eliminate the pathogen. Limited information has been obtained on the immune response to Map in healthy subjects and patients with CD. Understanding how Map may be involved in the pathogenesis of CD will require a better understanding of the immune response to Map in one of its common hosts as well as healthy humans and patients with CD.

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Title: Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue
Creators: William C Davis - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA. davisw@vetmed.wsu.edu
Sally A Madsen-Bouterse
Publication Details: Veterinary immunology and immunopathology, Vol.145(1-2), pp.1-6
Academic Unit: Veterinary Microbiology and Pathology, Department of
Publisher: Netherlands
Grant note: N01AI30055 / NIAID NIH HHS
Identifiers: 99900548213401842
Language: English
Resource Type: Journal article