Journal article
Cross-protective immunity induced by Babesia bovis clones with antigenically unrelated variable merozoite surface antigens
Veterinary immunology and immunopathology, Vol.41(3), pp.367-374
1994
Handle:
https://hdl.handle.net/2376/102041
PMID: 7941314
Abstract
Babesia bovis merozoite surface antigen 1 (MSA-1) induces antibodies capable of neutralizing merozoites in vitro. Both MSA-1 and the co-expressed MSA-2 are encoded by a polymorphic multigene family and are antigenically variant among strains isolated from widely separated geographic regions. In this study, cross-protective immunity between two
B. bovis clones, Mexico Mo-7 and Israel-C, that have antigenically unrelated MSA-1 and MSA-2 surface proteins was assessed. Cattle immunized by infection with either clone were significantly protected against challenge with the uncloned Israel Bbv strain. This indicates that epitopes capable of inducing partial protection are shared among different strains and that immunity is not solely dependent upon MSA-1 or MSA-2. However, cattle immunized with the Israel-C clone, derived from the Israel Bbv strain, were significantly better protected against BbV challenge than were cattle immunized with the Mexico Mo-7 clone bearing antigenically unrelated MSA-1 and MSA-2. The significant difference in immunity induced by the homologous strain versus an antigenically variant strain indicates that epitope variation among strains is relevant to immunity against babesiosis.
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Details
- Title
- Cross-protective immunity induced by Babesia bovis clones with antigenically unrelated variable merozoite surface antigens
- Creators
- Varda Shkap - Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, IsraelEugene Pipano - Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, IsraelTerry F McElwain - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USAUri Herzberg - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USAY Krigel - Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, IsraelL Fish - Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, IsraelGuy H Palmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Veterinary immunology and immunopathology, Vol.41(3), pp.367-374
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- Elsevier B.V
- Identifiers
- 99900546636301842
- Language
- English
- Resource Type
- Journal article