Journal article
Crossreactive neutralizing antibodies induced by immunization with caprine arthritis–encephalitis virus surface glycoprotein
Vaccine, Vol.18(13), pp.1282-1287
2000
Handle:
https://hdl.handle.net/2376/115828
PMID: 10649630
Abstract
Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis–encephalitis virus isolate 79–63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with SU in Quil A adjuvant. Sera from three goats neutralized an independent CAEV isolate (CAEV-Co). However, serum from one goat did not detectably neutralize heterologous CAEV-Co and inhibited CAEV-Co neutralization by another serum.
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Details
- Title
- Crossreactive neutralizing antibodies induced by immunization with caprine arthritis–encephalitis virus surface glycoprotein
- Creators
- R.K Kemp - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAD.P Knowles - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAL.L Perry - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAT.C McGuire - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAT.E Besser - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAW.P Cheevers - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA
- Publication Details
- Vaccine, Vol.18(13), pp.1282-1287
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900548149501842
- Language
- English
- Resource Type
- Journal article