Journal article
Cyclic ovarian hormone modulation of supraspinal Delta(9)-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat
Pharmacology, biochemistry and behavior, Vol.124, pp.269-277
09/01/2014
PMID: 24951841
Abstract
Estrous cycle-related fluctuations in delta-9-tetrahydrocannabinol (THC)-induced antinociception have been observed in the rat. The aim of this study was to determine which major ovarian hormone modulates the antinociceptive effects of i.c.v. THC, and whether hormone modulation of TI-IC's behavioral effects could be due to changes in brain cannabinoid receptors (CBr). Vehicle (oil) or hormones (estradiol or progesterone, or both) were administered to female rats on days 3 and 7 post-ovariectomy. On the morning or afternoon of day 8 or day 9, vehicle or THC (100 mu g) was administered i.c.v. Paw pressure, tail withdrawal, locomotor activity and catalepsy tests were conducted over a 3-h period. Estradiol (with and without progesterone) enhanced THC-induced paw pressure antinociception only. Ovarian hormones time-dependently modulated CBr in brain structures that mediate antinociception and locomotor activity, but the changes observed in CBr did not parallel changes in behavior. However, the time course of CBr changes must be further elucidated to determine the functional relationship between receptor changes and antinociceptive sensitivity to THC (C) 2014 Elsevier Inc. All rights reserved.
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Details
- Title
- Cyclic ovarian hormone modulation of supraspinal Delta(9)-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat
- Creators
- Alexa A. Wakley - Washington State UniversityAlisha A. McBride - Washington State UniversityLinda K. Vaughn - Marquette UniversityRebecca M. Craft - Washington State University
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.124, pp.269-277
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier
- Number of pages
- 9
- Identifiers
- 99900907904401842
- Language
- English
- Resource Type
- Journal article