Cyclic regulation of sensory perception by a female hormone alters behavior

Sandeepa Dey; Pablo Chamero-Benito; James K Pru; Ming-Shan Chien; Ximena Ibarra-Soria; Kathryn R Spencer; Darren W Logan; Hiroaki Matsunami; John J Peluso; Lisa Stowers

doi:10.1016/j.cell.2015.04.052

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Cyclic regulation of sensory perception by a female hormone alters behavior

Journal article

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Peer reviewed

Cyclic regulation of sensory perception by a female hormone alters behavior

Sandeepa Dey, Pablo Chamero-Benito, James K Pru, Ming-Shan Chien, Ximena Ibarra-Soria, Kathryn R Spencer, Darren W Logan, Hiroaki Matsunami, John J Peluso and Lisa Stowers

Cell (Cambridge), Vol.161(6), pp.1334-1344

2015

DOI: https://doi.org/10.1016/j.cell.2015.04.052

Handle:

https://hdl.handle.net/2376/118024

PMCID: PMC4501503

PMID: 26046438

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https://doi.org/10.1016/j.cell.2015.04.052View

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Abstract

Life Sciences

Females may display dramatically different behavior depending on their state of ovulation. This is thought to occur through sex-specific hormones acting on behavioral centers in the brain. Whether incoming sensory activity also differs across the ovulation cycle to alter behavior has not been investigated. Here, we show that female mouse vomeronasal sensory neurons (VSNs) are temporarily and specifically rendered "blind" to a subset of male-emitted pheromone ligands during diestrus yet fully detect and respond to the same ligands during estrus. VSN silencing occurs through the action of the female sex-steroid progesterone. Not all VSNs are targeted for silencing; those detecting cat ligands remain continuously active irrespective of the estrous state. We identify the signaling components that account for the capacity of progesterone to target specific subsets of male-pheromone responsive neurons for inactivation. These findings indicate that internal physiology can selectively and directly modulate sensory input to produce state-specific behavior. PAPERCLIP.

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Title: Cyclic regulation of sensory perception by a female hormone alters behavior
Creators: Sandeepa Dey - Scripps Research Institute
Pablo Chamero-Benito - Saarland University [Saarbrücken]
James K Pru - Washington State University
Ming-Shan Chien - Duke University Medical Center
Ximena Ibarra-Soria - The Wellcome Trust Sanger Institute [Cambridge]
Kathryn R Spencer - Scripps Research Institute
Darren W Logan - The Wellcome Trust Sanger Institute [Cambridge]
Hiroaki Matsunami - Duke University Medical Center
John J Peluso - University of Connecticut
Lisa Stowers - Scripps Research Institute
Publication Details: Cell (Cambridge), Vol.161(6), pp.1334-1344
Academic Unit: Animal Sciences, Department of
Publisher: Elsevier
Identifiers: 99900548132601842
Language: English
Resource Type: Journal article