Cycling Behavior and Memory Formation

Jason R Gerstner; Lisa C Lyons; Kenneth P Wright; Dawn H Loh; Oliver Rawashdeh; Kristin L Eckel-Mahan; Gregg W Roman

doi:10.1523/JNEUROSCI.3353-09.2009

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Cycling Behavior and Memory Formation

Jason R Gerstner, Lisa C Lyons, Kenneth P Wright, Dawn H Loh, Oliver Rawashdeh, Kristin L Eckel-Mahan and Gregg W Roman

The Journal of neuroscience, Vol.29(41), pp.12824-12830

Mini-Symposium

10/14/2009

DOI: https://doi.org/10.1523/JNEUROSCI.3353-09.2009

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https://hdl.handle.net/2376/101898

PMCID: PMC4077269

PMID: 19828795

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Abstract

Symposia and Mini-Symposia

Circadian research has spent considerable effort in the determining clock output pathways, including identifying both physiological and behavioral processes that demonstrate significant time-of-day variation. Memory formation and consolidation represent notable processes shaped by endogenous circadian oscillators. To date, very few studies on memory mechanisms have considered potential confounding effects of time-of-day and the organism's innate activity cycles (e.g., nocturnal, diurnal, or crepuscular). The following studies highlight recent work describing this interactive role of circadian rhythms and memory formation, and were presented at a mini-symposium at the 2009 annual meeting of the Society for Neuroscience. The studies illustrate these time-of-day observations in a variety of behavioral paradigms and model organisms, including olfactory avoidance conditioning in Drosophila , long-term sensitization in Aplysia , active-avoidance conditioning in Zebrafish, and classical fear conditioning in rodents, suggesting that the circadian influence on memory behavior is highly conserved across species. Evidence also exists for a conserved mechanistic relationship between specific cycling molecules and memory formation, and the extent to which proper circadian cycling of these molecules is necessary for optimal cognitive performance. Studies describe the involvement of the core clock gene period , as well as vasoactive intestinal peptide, melatonin, and the cAMP/MAPK (cAMP/mitogen-activated protein kinase) cascade. Finally, studies in humans describe evidence for alterations in cognitive performance based on an interaction between sleep–wake homeostasis and the internal circadian clock. Conservation of a functional relationship between circadian rhythms with learning and memory formation across species provides a critical framework for future analysis of molecular mechanisms underlying complex behavior.

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Title: Cycling Behavior and Memory Formation
Creators: Jason R Gerstner - Department of Genetics, University of Wisconsin–Madison, Madison, Wisconsin 53706
Lisa C Lyons - Department of Biological Science, Florida State University, Tallahassee, Florida 32306
Kenneth P Wright - Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309
Dawn H Loh - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90024
Oliver Rawashdeh - Department of Pharmacology and Toxicology, University at Buffalo, State University of New York (SUNY), Buffalo, New York 14214
Kristin L Eckel-Mahan - Department of Pharmacology, University of California, Irvine, Irvine, California 92697, and
Gregg W Roman - Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204
Publication Details: The Journal of neuroscience, Vol.29(41), pp.12824-12830
Academic Unit: Biomedical Sciences, Department of
Series: Mini-Symposium
Publisher: Society for Neuroscience
Identifiers: 99900546655901842
Language: English
Resource Type: Journal article