Journal article
Cytological studies of recombination in rhesus males
Cytogenetic and genome research, Vol.124(2), pp.132-138
05/2009
Handle:
https://hdl.handle.net/2376/101924
PMCID: PMC2919457
PMID: 19420925
Abstract
An immunofluorescence approach was used to directly examine meiotic recombination events in 483 pachytene spermatocytes from 11 male rhesus monkeys. Specifically, we examined the nuclear localization patterns of the DNA mismatch repair protein MLH1, known from analyses of other mammalian species to be a useful marker of meiotic cross-overs. Our results indicated that rhesus pachytene spermatocytes contain approximately 40 cross-overs per cell, corresponding to about one cross-over per chromosome. The chromosomal distribution of these exchanges was consistent with data from human and mouse males but, surprisingly, the overall number of foci was lower, and the number of ‘exchangeless’ bivalents higher, than reported for either humans or mice.
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Details
- Title
- Cytological studies of recombination in rhesus males
- Creators
- T Hassold - School of Molecular Biosciences, Washington State University, Pullman, WA (USA)T Hansen - School of Molecular Biosciences, Washington State University, Pullman, WA (USA)P Hunt - School of Molecular Biosciences, Washington State University, Pullman, WA (USA)C VandeVoort - California National Primate Research Center, University of California, Davis, CA (USA)
- Publication Details
- Cytogenetic and genome research, Vol.124(2), pp.132-138
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- S. Karger AG; Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch
- Identifiers
- 99900546512801842
- Language
- English
- Resource Type
- Journal article