Journal article
Cytoplasmic to nuclear localization of fatty-acid binding protein correlates with specific forms of long-term memory in Drosophila
Communicative & integrative biology, Vol.4(5), pp.623-626
2011
Handle:
https://hdl.handle.net/2376/107630
PMCID: PMC3204147
PMID: 22046481
Abstract
We recently reported evidence implicating fatty-acid binding protein (Fabp) in the control of sleep and memory formation. We used
Drosophila melanogaster
to examine the relationship between sleep and memory through transgenic overexpression of mouse brain-Fabp, Fabp7, or the Drosophila Fabp homolog, (dFabp). The key findings are that 1) a genetically induced increase in daytime consolidated sleep (naps) correlates with an increase in cognitive performance, and 2) a late “window” of memory consolidation occurs days after the traditionally understood “synaptic” consolidation. Exactly how Fabp-signaling may be involved in converting normal to enhanced long-term memory (LTM) is not known. Here we describe additional data which support relative subcellular compartmental localization of Fabp in regulating stage associations of different forms of memory in Drosophila. Anesthesia resistant memory (ARM) is a longer lasting memory that is produced by massed training, but unlike LTM produced by spaced training, it is insensitive to protein synthesis inhibitors and does not persist as long. We observed that the ratio of ARM to LTM performance index of Fabp7-transgenic flies is proportional to the relative cytoplasmic to nuclear Fabp7 expression level. These data suggest a common lipid-signaling cascade exists between phases of memory formation previously thought to be molecularly distinct.
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Details
- Title
- Cytoplasmic to nuclear localization of fatty-acid binding protein correlates with specific forms of long-term memory in Drosophila
- Creators
- Jason R Gerstner - Center for Sleep and Circadian Neurobiology; University of Pennsylvania; Philadelphia, PA USAWilliam M Vanderheyden - Department of Anatomy; Washington University Medical School; Saint Louis, MO USAPaul J Shaw - Department of Anatomy; Washington University Medical School; Saint Louis, MO USACharles F Landry - Scarab Genomics; University of Wisconsin; Madison, WI USAJerry CP Yin - Department of Neurology; University of Wisconsin; Madison, WI USA
- Publication Details
- Communicative & integrative biology, Vol.4(5), pp.623-626
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- Landes Bioscience
- Identifiers
- 99900547260701842
- Language
- English
- Resource Type
- Journal article