Journal article
Cytoprotective effects of hydrogen sulfide-releasing N-methyl-d-aspartate receptor antagonists mediated by intracellular sulfane sulfur
MedChemComm, Vol.5(10), pp.1577-1583
09/24/2014
Handle:
https://hdl.handle.net/2376/109130
PMCID: PMC4242466
PMID: 25431645
Abstract
Hydrogen sulfide (H2S) exerts a host of biological effects ranging from cytotoxicity to cytoprotection. Cytotoxicity of H2S in neurodegenerative diseases may be mediated by N-methyl-d-aspartate receptor (NMDAR) activation. To exploit cytoprotective effects of H2S while minimizing its toxicity, we synthesized a series of H2S-releasing NMDAR antagonists and examined their effects against 1-methyl-4-phenylpyridinium (MPP+)-induced cell death, a cellular model of Parkinson's disease. We observed that cytoprotective effects of H2S-releasing NMDAR antagonists correlated with their ability to increase intracellular sulfane sulfur, but not H2S, levels. These studies suggest that H2S-donor compounds that increase intracellular sulfane sulfur levels are potentially useful neuroprotective agents against neurodegenerative diseases.
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Details
- Title
- Cytoprotective effects of hydrogen sulfide-releasing N-methyl-d-aspartate receptor antagonists mediated by intracellular sulfane sulfur
- Creators
- Eizo Marutani - Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USAMasahiro Sakaguchi - Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USAWei Chen - Department of Chemistry, Washington State University, Pullman, USAKiyoshi Sasakura - Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanJifeng Liu - Aberjona Laboratories, Inc., Beverly, USAMing Xian - Department of Chemistry, Washington State University, Pullman, USAKenjiro Hanaoka - Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanTetsuo Nagano - Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanFumito Ichinose - Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
- Publication Details
- MedChemComm, Vol.5(10), pp.1577-1583
- Academic Unit
- Chemistry, Department of
- Identifiers
- 99900547299701842
- Language
- English
- Resource Type
- Journal article