DIFFERENTIAL IMMUNOGENICITY OF VACCINIA AND HIV-1 COMPONENTS OF A HUMAN RECOMBINANT VACCINE IN MUCOSAL AND BLOOD COMPARTMENTS

Peter A Anton; F Javier Ibarrondo; W. John Boscardin; Ying Zhou; Elissa J Schwartz; Hwee L Ng; Mary Ann Hausner; Roger Shih; Julie Elliott; Patricia M Hultin; Lance E Hultin; Charles Price; Marie Fuerst; Amy Adler; Johnson T Wong; Otto O Yang; Beth D Jamieson

doi:10.1016/j.vaccine.2008.05.084

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DIFFERENTIAL IMMUNOGENICITY OF VACCINIA AND HIV-1 COMPONENTS OF A HUMAN RECOMBINANT VACCINE IN MUCOSAL AND BLOOD COMPARTMENTS

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DIFFERENTIAL IMMUNOGENICITY OF VACCINIA AND HIV-1 COMPONENTS OF A HUMAN RECOMBINANT VACCINE IN MUCOSAL AND BLOOD COMPARTMENTS

Peter A Anton, F Javier Ibarrondo, W. John Boscardin, Ying Zhou, Elissa J Schwartz, Hwee L Ng, Mary Ann Hausner, Roger Shih, Julie Elliott, Patricia M Hultin, …

Vaccine, Vol.26(35), pp.4617-4623

08/18/2008

DOI: https://doi.org/10.1016/j.vaccine.2008.05.084

Handle:

https://hdl.handle.net/2376/116573

PMCID: PMC2570228

PMID: 18621451

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https://doi.org/10.1016/j.vaccine.2008.05.084View

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Abstract

HIV

vaccine

mucosal immunity

Mucosal immune responses induced by HIV-1 vaccines are likely critical for prevention. We report a Phase 1 safety and immunogenicity trial in 8 participants using the vaccinia -based TBC-3B vaccine given subcutaneously to determine the relationship between HIV-1 specific systemic and gastrointestinal mucosal responses. Across all subjects, detectable levels of blood vaccinia - and HIV-1-specific antibodies were elicited but none were seen mucosally. While the vaccinia component was immunogenic for CD8 + T lymphocyte (CTL) responses in both blood and mucosa, it was greater in blood. The HIV-1 component of the vaccine was poorly immunogenic in both blood and mucosa. Although only 8 volunteers were studied intensively, the discordance between mucosal and blood responses may highlight mechanisms contributing to recent vaccine failures.

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Title: DIFFERENTIAL IMMUNOGENICITY OF VACCINIA AND HIV-1 COMPONENTS OF A HUMAN RECOMBINANT VACCINE IN MUCOSAL AND BLOOD COMPARTMENTS
Creators: Peter A Anton - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
F Javier Ibarrondo - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
W. John Boscardin - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Ying Zhou - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Elissa J Schwartz - Department of Mathematics and School of Biological Sciences, Washington State University, Pullman, WA
Hwee L Ng - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Mary Ann Hausner - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Roger Shih - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Julie Elliott - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Patricia M Hultin - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Lance E Hultin - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Charles Price - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Marie Fuerst - Tower Cancer Research Foundation, Beverly Hills, CA
Amy Adler - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Johnson T Wong - Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Otto O Yang - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Beth D Jamieson - UCLA AIDS Institute and Department of Medicine, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Publication Details: Vaccine, Vol.26(35), pp.4617-4623
Academic Unit: Biological Sciences, School of
Identifiers: 99900547993001842
Language: English
Resource Type: Journal article