Journal article
DNA Damage and Repair: Fruit and Vegetable Effects in a Feeding Trial
Nutrition and cancer, Vol.62(3), pp.329-335
04/05/2010
Handle:
https://hdl.handle.net/2376/109558
PMCID: PMC3799895
PMID: 20358470
Abstract
Epidemiologic studies have examined the association between fruit and vegetable (F&V) consumption and the risk of cancer. Several cancer-preventive mechanisms have been proposed, such as antioxidant properties and modulation of biotransformation enzyme activities; both may be associated with reducing DNA damage and hence the mutation rate. We investigated, in a randomized, controlled, crossover feeding trial, the effect of 10 servings/day of botanically defined F&V for 2 wk on endogenous DNA damage; resistance to γ -irradiation damage; and DNA repair capacity in lymphocytes, measured by the Comet assay. We also explored the association between the UGT1A1*28 polymorphism and serum bilirubin concentrations and DNA damage and repair measures. Healthy men (n = 11) and women (n = 17), age 20 to 40 yr, provided blood samples at the end of each feeding period. Overall, F&V did not affect DNA damage and repair measures in lymphocytes. The number of UGT1A1*28 alleles was inversely associated with sensitivity to γ -irradiation exposure and DNA repair capacity, but a biological mechanism to explain this association is unclear. A larger sample size is needed to investigate the association between bilirubin concentrations and endogenous DNA damage. With inconsistent findings in the literature, additional dietary intervention studies on the effect of F&V on DNA damage and repair are needed.
Metrics
3 Record Views
Details
- Title
- DNA Damage and Repair: Fruit and Vegetable Effects in a Feeding Trial
- Creators
- Jyh-Lurn Chang - Fred Hutchinson Cancer Research CenterGang Chen - Pennsylvania State UniversityCornelia M Ulrich - Fred Hutchinson Cancer Research CenterJeannette Bigler - Fred Hutchinson Cancer Research CenterIrena B King - Fred Hutchinson Cancer Research CenterYvonne Schwarz - Fred Hutchinson Cancer Research CenterShiuying Li - Fred Hutchinson Cancer Research CenterLin Li - Fred Hutchinson Cancer Research CenterJohn D Potter - Fred Hutchinson Cancer Research CenterJohanna W Lampe - Fred Hutchinson Cancer Research Center
- Publication Details
- Nutrition and cancer, Vol.62(3), pp.329-335
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Taylor & Francis Group
- Identifiers
- 99900547542201842
- Language
- English
- Resource Type
- Journal article