Journal article
DNA rearrangements and altered transcripts of the MLL gene in a human T‐all cell line karpas 45 with a t(X;II) (q13;q23) translocation
Genes chromosomes & cancer, Vol.9(3), pp.221-224
03/1994
Handle:
https://hdl.handle.net/2376/114022
PMID: 7515665
Abstract
Translocations involving chromosome band 11q23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, and we have recently reported that rearrangement of the MLL gene is involved in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4, 6, 9, and 19, and we and others have reported that chromosomes 1, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t(X;II) (q13;q23) translocation, we report here that the MLL gene is rearranged and that there are two altered transcripts of MLL that come from the der(11) chromosome. Genes Chrom Cancer 9:221‐224 (1994). © 1994 Wiley‐Liss, Inc.
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Details
- Title
- DNA rearrangements and altered transcripts of the MLL gene in a human T‐all cell line karpas 45 with a t(X;II) (q13;q23) translocation
- Creators
- Norah R McCabeMagdalena KipiniakHirofumi KobayashiMichael ThirmanHeidi GillJanet D RowleyManuel O Diaz
- Publication Details
- Genes chromosomes & cancer, Vol.9(3), pp.221-224
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; New York
- Number of pages
- 4
- Grant note
- Illinois‐Eastern Iowa District of Kiwanis International(J.D.R. and M.O.D.) National Institute of Health (CA42557 (J.D.R.); CA38725 (M.O.D.)) Spastic Paralysis Research Foundation
- Identifiers
- 99900548482301842
- Language
- English
- Resource Type
- Journal article