Journal article
DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina
Neuron (Cambridge, Mass.), Vol.64(4), pp.484-497
2009
Handle:
https://hdl.handle.net/2376/116853
PMCID: PMC2850049
PMID: 19945391
Abstract
DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In addition to a subset of amacrine cells,
Dscam was expressed in most retinal ganglion cells (RGCs). RGCs had fasciculated dendrites and clumped cell bodies in
Dscam
−/− mice, suggesting a role in self-avoidance.
Dscaml1 was expressed in the rod circuit, and mice lacking
Dscaml1 had fasciculated rod bipolar cell dendrites and clumped AII amacrine cell bodies, also indicating a role in self-avoidance. Neurons in
Dscam or
Dscaml1 mutant retinas stratified their processes appropriately in synaptic laminae in the inner plexiform layer, and functional synapses formed in the rod circuit in mice lacking
Dscaml1. Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina.
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Details
- Title
- DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina
- Creators
- Peter G Fuerst - The Jackson Laboratory, Bar Harbor, ME 04609, USAFreyja Bruce - School of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UKMiao Tian - Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAWei Wei - University of California, BerkeleyJustin Elstrott - Department of Molecular Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USAMarla B Feller - Department of Molecular Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USALynda Erskine - School of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UKJoshua H Singer - Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USARobert W Burgess - The Jackson Laboratory, Bar Harbor, ME 04609, USA
- Publication Details
- Neuron (Cambridge, Mass.), Vol.64(4), pp.484-497
- Academic Unit
- Department of Plant Pathology ; Center for Reproductive Biology
- Publisher
- Elsevier Inc
- Identifiers
- 99900548172701842
- Language
- English
- Resource Type
- Journal article