Journal article
Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques
Aviation, space, and environmental medicine, Vol.75(3 Suppl), pp.A147-A154
03/2004
Handle:
https://hdl.handle.net/2376/103304
PMID: 15018277
Abstract
Inter-individual differences in performance impairment from sleep loss are substantial and consistent, as demonstrated and quantified here by means of the intraclass correlation coefficient (ICC) in two laboratory-based sleep deprivation studies. There is an urgent need, therefore, to consider inter-individual variability in biomathematical models of fatigue and performance, which currently treat individuals as being all the same. Traditional regression techniques do not handle inter-individual variability, but cutting-edge mixed-effects modeling techniques have recently become available to deal with inter-individual differences in the temporal dynamics of fatigue and performance. The standard two stage (STS), restricted maximum likelihood (REML), and non-linear mixed-effects modeling (NMEM) approaches to mixed-effects models are compared here using data from a chronic partial sleep deprivation experiment. Mixed-effects modeling can be incorporated in the two distinct steps (the direct and inverse problems) of biomathematical model development in order to deal with inter-individual differences. This paper demonstrates that inter-individual variability accounts for a large percentage of observed variance in neurobehavioral responses to sleep deprivation, and describes tools that model developers will need to produce a new generation of fatigue and performance models capable of incorporating inter-individual variability and useful for subject-specific prediction.
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Details
- Title
- Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques
- Creators
- Hans P A Van Dongen - Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA. vdongen@mail.med.upenn.eduGreg MaislinDavid F Dinges
- Publication Details
- Aviation, space, and environmental medicine, Vol.75(3 Suppl), pp.A147-A154
- Academic Unit
- Medical Education and Clinical Science, Department of
- Publisher
- United States
- Grant note
- RR00040 / NCRR NIH HHS HL70154 / NHLBI NIH HHS NR04281 / NINR NIH HHS
- Identifiers
- 99900546799701842
- Language
- English
- Resource Type
- Journal article