Journal article
Decreased Infectivity of a Neutralization-Resistant Equine Infectious Anemia Virus Variant Can Be Overcome by Efficient Cell-to-Cell Spread
Journal of virology, Vol.85(19), pp.10421-10424
10/2011
Handle:
https://hdl.handle.net/2376/110836
PMCID: PMC3196457
PMID: 21752904
Abstract
Two variants of equine infectious anemia virus (EIAV) that differed in sensitivity to broadly neutralizing antibody were tested in direct competition assays. No differences were observed in the growth curves and relative fitness scores of EIAVs of principal neutralizing domain variants of groups 1 (EIAV
PND-1
) and 5 (EIAV
PND-5
), respectively; however, the neutralization-resistant EIAV
PND-5
variant was less infectious in single-round replication assays. Infectious center assays indicated similar rates of cell-to-cell spread, which was approximately 1,000-fold more efficient than cell-free infectivity. These data indicate that efficient cell-to-cell spread can overcome the decreased infectivity that may accompany immune escape and should be considered in studies assessing the relative levels of fitness among lentivirus variants, including HIV-1.
Metrics
12 Record Views
Details
- Title
- Decreased Infectivity of a Neutralization-Resistant Equine Infectious Anemia Virus Variant Can Be Overcome by Efficient Cell-to-Cell Spread
- Creators
- Wuwei Wu - Departments of Animal ScienceDerek C Blythe - StatisticsHyelee Loyd - Departments of Animal ScienceRobert H Mealey - Iowa State University, Ames, Iowa 50011, and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164Rebecca L Tallmadge - Iowa State University, Ames, Iowa 50011, and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164Karin S Dorman - StatisticsSusan Carpenter - Departments of Animal Science
- Publication Details
- Journal of virology, Vol.85(19), pp.10421-10424
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- Identifiers
- 99900547129301842
- Language
- English
- Resource Type
- Journal article