Journal article
Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep
Frontiers in genetics, Vol.10, pp.300-300
2019
Handle:
https://hdl.handle.net/2376/113400
PMCID: PMC6454055
PMID: 31001329
Abstract
Sheep were one of the earliest domesticated animals. Both artificial and natural selection during domestication has resulted in remarkable changes in behavioral, physiological, and morphological phenotypes; however, the genetic mechanisms underpinning these changes remain unclear, particularly for indigenous Chinese sheep. In the present study, we performed pooled whole-genome resequencing of 338 sheep from five breeds representative of indigenous Chinese breeds and compared them to the wild ancestors of domestic sheep (Asian mouflon,
Ovis orientalis
) for detection of genome-wide selective sweeps. Comparative genomic analysis between domestic sheep and Asian mouflon showed that selected regions were enriched for genes involved in bone morphogenesis, growth regulation, and embryonic and neural development in domestic sheep. Moreover, we identified several vision-associated genes with funtional mutations, such as
PDE6B
(c.G2994C/p.A982P and c.C2284A/p.L762M mutations),
PANK2
, and
FOXC1/GMSD
in all five Chinese native breeds. Breed-specific selected regions were determined including genes such as
CYP17
for hypoxia adaptability in Tibetan sheep and
DNAJB5
for heat tolerance in Duolang sheep. Our findings provide insights into the genetic mechanisms underlying important phenotypic changes that have occurred during sheep domestication and subsequent selection.
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Details
- Title
- Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep
- Creators
- Weimin Wang - College of Animal Science and Technology, Gansu Agricultural UniversityXiaoxue Zhang - College of Animal Science and Technology, Gansu Agricultural UniversityXiang Zhou - Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural UniversityYangzi Zhang - Department of Animal Sciences, Washington State UniversityYongfu La - College of Animal Science and Technology, Gansu Agricultural UniversityYu Zhang - Department of Animal Sciences, Washington State UniversityChong Li - College of Animal Science and Technology, Gansu Agricultural UniversityYouzhang Zhao - College of Animal Science and Technology, Gansu Agricultural UniversityFadi Li - College of Animal Science and Technology, Gansu Agricultural UniversityBang Liu - Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural UniversityZhihua Jiang - Department of Animal Sciences, Washington State University
- Publication Details
- Frontiers in genetics, Vol.10, pp.300-300
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Frontiers Media S.A
- Identifiers
- 99900548111301842
- Language
- English
- Resource Type
- Journal article