Journal article
Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae
IUBMB life, Vol.63(8), pp.659-667
08/2011
Handle:
https://hdl.handle.net/2376/117126
PMID: 21766412
Abstract
The endothelial cell monolayer lining the vessel wall forms a size-selective, semi-permeable barrier between the blood and tissue that must be crossed by blood borne therapeutic agents to reach diseased extravascular tissue. Nanoparticles engineered to carry drugs present an opportunity to enhance the specificity and efficacy of drug delivery. Therefore, an understanding of how these engineered nanoparticles are transported across the vessel wall will help us to more fully exploit this powerful therapeutic technology. Vascular endothelial cells are rich in caveolae, cell surface invaginations 50-100 nm in diameter that mediate endocytosis of lipids, proteins, and viruses. Caveolar invaginations pinch off to form intracellular vesicles that can transport cargo across the cell and release the cargo into the extravascular space via exocytosis. Here, we will review the current concepts and state of development for delivering engineered nanoparticles across the endothelium via the caveolae-mediated pathway.
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Details
- Title
- Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae
- Creators
- Zhenjia Wang - Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, USAChinnaswamy TiruppathiJaehyung ChoRichard D MinshallAsrar B Malik
- Publication Details
- IUBMB life, Vol.63(8), pp.659-667
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- England
- Grant note
- P01 HL077806 / NHLBI NIH HHS P01 HL060678 / NHLBI NIH HHS R01 HL045638 / NHLBI NIH HHS P01 HL060678-10 / NHLBI NIH HHS P01HL060678 / NHLBI NIH HHS R01 HL045638-22 / NHLBI NIH HHS P01 HL077806-06 / NHLBI NIH HHS UL1RR029879 / NCRR NIH HHS UL1 RR029879 / NCRR NIH HHS P01 HL060678-11A1 / NHLBI NIH HHS P01HL077806 / NHLBI NIH HHS P01 HL077806-07 / NHLBI NIH HHS R01 HL045638-23 / NHLBI NIH HHS R01HL045638 / NHLBI NIH HHS
- Identifiers
- 99900548043801842
- Language
- English
- Resource Type
- Journal article