Journal article
Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats
Journal of headache and pain, Vol.18(1), pp.1-8
12/2017
Handle:
https://hdl.handle.net/2376/112688
PMCID: PMC5236037
PMID: 28091820
Abstract
The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can be mimicked in rats. The goal of the present study was to test the hypothesis thatdepression of home cage wheel running is a reliable and clinically relevant method to assess migraine painin rats.Adult female rats were implanted with a cannula to inject allyl isothiocyanate (AITC) onto the dura to induce migraine pain, as has been shown before. Rats recovered from implantation surgery for 8 days in cages containing a running wheel. Home cage wheel running was recorded 23 h a day. AITC and the migraine medication sumatriptan were administered in the hour prior to onset of the dark phase.Administration of AITC caused a concentration-dependent decrease in wheel running that lasted 3 h. The duration and magnitude of AITC-induced depression of wheel running was consistent following three repeated injections spaced 48 h apart. Administration of sumatriptan attenuated AITC-induced depressionof wheel running when a large dose (1 mg/kg) was administered immediately following AITC administration. Wheel running patterns did not change when sumatriptan was given to naïve rats.These data indicate that home cage wheel running is a sensitive, reliable, and clinically relevant method to assess migraine pain in the rat.
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Details
- Title
- Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats
- Creators
- Ram Kandasamy - Washington State University Vancouver 14204 NE Salmon Creek Ave Vancouver WA 98686 USAAndrea Lee - Department of Psychology Washington State University Vancouver Vancouver WA USAMichael Morgan - Department of Psychology Washington State University Vancouver Vancouver WA USA
- Publication Details
- Journal of headache and pain, Vol.18(1), pp.1-8
- Academic Unit
- Psychology, Department of
- Publisher
- Springer Milan; Milan
- Grant note
- State of Washington Initiative Measure No. 171 State of Washington Initiative Measure No. 502 NS095097 / National Institute of Neurological Disorders and Stroke (http://dx.doi.org/10.13039/100000065)
- Identifiers
- 99900548098501842
- Language
- English
- Resource Type
- Journal article