Journal article
Determining Ethyl Glucuronide Cutoffs When Detecting Self‐Reported Alcohol Use in Addiction Treatment Patients
Alcoholism, clinical and experimental research, Vol.39(5), pp.905-910
05/2015
Handle:
https://hdl.handle.net/2376/105502
PMCID: PMC4400217
PMID: 25866234
Abstract
Background
Ethyl glucuronide (EtG) is an alcohol biomarker with potential utility as a clinical research and alcohol treatment outcome. Debate exists regarding the appropriate cutoff level for determining alcohol use, particularly with the EtG immunoassay. This study determined the EtG immunoassay cutoff levels that most closely correspond to self‐reported drinking in alcohol‐dependent outpatients.
Methods
Eighty adults with alcohol dependence and mental illness, taking part in an alcohol treatment study, provided urine samples 3 times per week for up to 16 weeks (1,589 samples). Self‐reported drinking during 120 hours prior to each sample collection was assessed. Receiver operating characteristic analyses were conducted to assess the ability of the EtG immunoassay to detect self‐reported alcohol use across 24‐ to 120‐hour time periods. Sensitivity and specificity of EtG immunoassay cutoff levels was compared in 100 ng/ml increments (100 to 500 ng/ml) across 24 to 120 hours.
Results
Over half (57%) of the 1,589 samples indicated recent alcohol consumption. The EtG immunoassay closely corresponded to self‐reported drinking from 24 (area under the curve [AUC] = 0.90, 95% confidence interval [CI]: 0.88, 0.92) to 120 hours (AUC = 0.88, 95% CI: 0.87, 0.90). When cutoff levels were compared across 24 to 120 hours, 100 ng/ml had the highest sensitivity (0.93 to 0.78) and lowest specificity (0.67 to 0.85). Relative to 100 ng/ml, the 200 ng/ml cutoff demonstrated a reduction in sensitivity (0.89 to 0.67), but improved specificity (0.78 to 0.94). The 300, 400, and 500 ng/ml cutoffs demonstrated the lowest sensitivity (0.86 to 0.33) and highest specificity (0.86 to 0.97) over 24 to 120 hours.
Conclusions
For detecting alcohol use for >24 hours, the 200 ng/ml cutoff level is recommended for use as a research and clinical outcome.
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Details
- Title
- Determining Ethyl Glucuronide Cutoffs When Detecting Self‐Reported Alcohol Use in Addiction Treatment Patients
- Creators
- Jessica M Lowe - University of WashingtonMichael G McDonell - University of WashingtonEmily Leickly - University of WashingtonFrank A Angelo - University of WashingtonRoger Vilardaga - University of Washington & Fred Hutchinson Cancer Research CenterSterling McPherson - Washington State UniversityDebra Srebnik - University of WashingtonJohn Roll - Washington State UniversityRichard K Ries - University of Washington
- Publication Details
- Alcoholism, clinical and experimental research, Vol.39(5), pp.905-910
- Academic Unit
- Elson S. Floyd College of Medicine; Medical Education and Clinical Science, Department of
- Number of pages
- 6
- Grant note
- National Institutes of Health (R01AA020248‐01; 1K99DA037276‐01)
- Identifiers
- 99900546901701842
- Language
- English
- Resource Type
- Journal article