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Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection
Journal article   Open access  Peer reviewed

Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection

Cristina W Cunha, Travis C McGuire, Lowell S Kappmeyer, Stephen A Hines, A Marianela Lopez, Odir A Dellagostin and Donald P Knowles
Clinical and vaccine immunology, Vol.13(2), pp.297-300
02/2006
DOI: https://doi.org/10.1128/CVI.13.2.297-300.2006
Handle:
https://hdl.handle.net/2376/114681
PMCID: PMC1391941
PMID: 16467341
url
https://doi.org/10.1128/CVI.13.2.297-300.2006View
Published (Version of record) Open

Abstract

Enzyme-Linked Immunosorbent Assay Parasitemia - immunology Babesiosis - veterinary Parasitemia - veterinary Babesia - immunology Immunoglobulin G - classification Horse Diseases - parasitology Antibodies, Protozoan - biosynthesis Immunoglobulin Isotypes - biosynthesis Animals Babesiosis - parasitology Babesiosis - immunology Immunoglobulin G - biosynthesis Time Factors Horses Parasitemia - parasitology Horse Diseases - immunology
In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute parasitemia. The same IgG isotype profile induced during acute infection was obtained by equi merozoite antigen 1/saponin immunization.

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