Files and links (2)
CC BY-NC V4.0, Open Access
Journal article
Developmental origins of epigenetic transgenerational inheritance
Environmental epigenetics, Vol.2(1), p.dvw002
2016
Handle:
https://hdl.handle.net/2376/102851
PMCID: PMC4933018
PMID: 27390622
Abstract
Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance and has been shown in a variety of species including plants, flies, worms, fish, rodents, pigs, and humans. This phenomenon operates during specific critical windows of exposure, linked to the developmental biology of the germ cells (sperm and eggs). Therefore, concepts of the developmental origins of transgenerational inheritance of phenotypic variation and subsequent disease risk need to include epigenetic processes affecting the developmental biology of the germ cell. These developmental impacts on epigenetic transgenerational inheritance, in contrast to multigenerational exposures, are the focus of this Perspective.
Metrics
14 Record Views
Details
- Title
- Developmental origins of epigenetic transgenerational inheritance
- Creators
- Mark A Hanson - Institute of Developmental Sciences, University of Southampton and NIHR Nutrition Biomedical Research Centre, Southampton General Hospital, Southampton, SO 16 6YD, UKMichael K Skinner - School of Biological Sciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164-4236, USA
- Publication Details
- Environmental epigenetics, Vol.2(1), p.dvw002
- Academic Unit
- Biological Sciences, School of
- Publisher
- Oxford Univ Press; England
- Number of pages
- 9
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900546674901842
- Language
- English
- Resource Type
- Journal article