Journal article
Diazepam dissociates the analgesic and aversive effects of periaqueductal gray stimulation in the rat
Brain research, Vol.423(1), pp.395-398
1987
Handle:
https://hdl.handle.net/2376/104294
PMID: 3676817
Abstract
Electrical stimulation of the periaqueductal gray matter (PAG) of the rat can produce both analgesia and aversive reactions. To determine if these two effects can be dissociated, diazepam, a benzodiazepine, was administered to rats chronically implanted with electrodes in the PAG. The threshold for stimulation-produced analgesia or aversion, whichever was lowest, was determined before and after drug administration. Diazepam (1 mg/kg) attenuated stimulation-produced aversive reactions at 12 of 20 stimulation sites, allowing analgesia to be measured at the same threshold. Diazepam did not alter baseline pain sensitivity or thresholds for stimulation-produced analgesia. These results indicate that aversive reactions and analgesia from PAG stimulation can be pharmacologically dissociated.
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Details
- Title
- Diazepam dissociates the analgesic and aversive effects of periaqueductal gray stimulation in the rat
- Creators
- Michael M MorganAntoine DepaulisJohn C Liebeskind
- Publication Details
- Brain research, Vol.423(1), pp.395-398
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546829601842
- Language
- English
- Resource Type
- Journal article