Journal article
Dichloroacetate Therapy Attenuates the Blood Lactate Response to Submaximal Exercise in Patients with Defects in Mitochondrial Energy Metabolism
The journal of clinical endocrinology and metabolism, Vol.89(4), pp.1733-1738
04/01/2004
Handle:
https://hdl.handle.net/2376/106029
PMID: 15070938
Abstract
Abstract We determined acute and chronic effects of dichloroacetate (DCA) on maximal (MAX) and submaximal (SUB) exercise responses in patients with abnormal mitochondrial energetics. Subjects (n = 9) completed a MAX treadmill bout 1 h after ingesting 25 mg/kg DCA or placebo (PL). A 15-min SUB bout was completed the next day while receiving the same treatment. After a 1-d washout, MAX and SUB were repeated while receiving the alternate treatment (acute). Gas exchange and heart rate were measured throughout all tests. Blood lactate (Bla) was measured 0, 3, and 10 min after MAX, and 5, 10, and 15 min during SUB. MAX and SUB were repeated after 3 months of daily DCA or PL. After a 2-wk washout, a final MAX and SUB were completed after 3 months of alternate treatment (chronic). Average Bla during SUB was lower (P < 0.05) during both acute (1.99 ± 1.10 vs. 2.49 ± 1.52 mmol/liter) and chronic (1.71 ± 1.37 vs. 2.39 ± 1.32 mmol/liter) DCA vs. PL despite similar exercise intensities between conditions (∼75 and 70% maximal exercise capacity during acute and chronic treatment). Thus, although DCA does not alter MAX responses, acute and chronic DCA attenuate the Bla response to moderate exercise in patients with abnormal mitochondrial energetics.
Metrics
13 Record Views
Details
- Title
- Dichloroacetate Therapy Attenuates the Blood Lactate Response to Submaximal Exercise in Patients with Defects in Mitochondrial Energy Metabolism
- Creators
- G. E Duncan - Department of Epidemiology, Nutritional Sciences Program, University of Washington (G.E.D.), Seattle, Washington 98195L. A Perkins - Departments of Medicine (L.A.P., P.W.S.), Gainesville, Florida 32610D. W Theriaque - General Clinical Research Center (D.W.T.), University of Florida, Gainesville, Florida 32610R. E Neiberger - Pediatrics (R.E.N.), Gainesville, Florida 32610P. W Stacpoole - Departments of Medicine (L.A.P., P.W.S.), Gainesville, Florida 32610, Biochemistry and Molecular Biology (P.W.S.), Gainesville, Florida 32610
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.89(4), pp.1733-1738
- Academic Unit
- Nutrition and Exercise Physiology, Department of
- Identifiers
- 99900546984901842
- Language
- English
- Resource Type
- Journal article