Journal article
Directing the Immune System with Chemical Compounds
ACS chemical biology, Vol.9(5), pp.1075-1085
05/16/2014
Handle:
https://hdl.handle.net/2376/112571
PMID: 24690004
Abstract
Agonists of immune cell receptors direct innate and adaptive immunity. These agonists range in size and complexity from small molecules to large macromolecules. Here, agonists of a class of immune cell receptors known as the Toll-like receptors (TLRs) are highlighted focusing on the distinctive molecular moieties that pertain to receptor binding and activation. How the structure and combined chemical signals translate into a variety of immune responses remain major questions in the field. In this structure-focused review, we outline potential areas where the tools of chemical biology could help decipher the emerging molecular codes that direct immune stimulation.
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Details
- Title
- Directing the Immune System with Chemical Compounds
- Creators
- Rock J Mancini - Department of Chemistry, Chemical Engineering and Materials Science, and Biomedical Engineering, University of California Irvine, 1102 Natural Sciences 2, Irvine, California 92697-2025, United StatesLalisa Stutts - Department of Chemistry, Chemical Engineering and Materials Science, and Biomedical Engineering, University of California Irvine, 1102 Natural Sciences 2, Irvine, California 92697-2025, United StatesKeun Ah Ryu - Department of Chemistry, Chemical Engineering and Materials Science, and Biomedical Engineering, University of California Irvine, 1102 Natural Sciences 2, Irvine, California 92697-2025, United StatesJanine K Tom - Department of Chemistry, Chemical Engineering and Materials Science, and Biomedical Engineering, University of California Irvine, 1102 Natural Sciences 2, Irvine, California 92697-2025, United StatesAaron P Esser-Kahn - Department of Chemistry, Chemical Engineering and Materials Science, and Biomedical Engineering, University of California Irvine, 1102 Natural Sciences 2, Irvine, California 92697-2025, United States
- Publication Details
- ACS chemical biology, Vol.9(5), pp.1075-1085
- Academic Unit
- Department of Chemistry
- Identifiers
- 99900547911301842
- Language
- English
- Resource Type
- Journal article