Journal article
Discovery of a Gene Conferring Multiple-Aminoglycoside Resistance in Escherichia coli
Antimicrobial agents and chemotherapy, Vol.54(6), pp.2666-2669
06/2010
Handle:
https://hdl.handle.net/2376/114009
PMCID: PMC2876372
PMID: 20368404
Abstract
Bovine-origin Escherichia coli isolates were tested for resistance phenotypes using a disk diffusion assay and for resistance genotypes using a DNA microarray. An isolate with gentamicin and amikacin resistance but with no corresponding genes detected yielded a 1,056-bp DNA sequence with the closest homologues for its inferred protein sequence among a family of 16S rRNA methyltransferase enzymes. These enzymes confer high-level aminoglycoside resistance and have only recently been described in Gram-negative bacteria.
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Details
- Title
- Discovery of a Gene Conferring Multiple-Aminoglycoside Resistance in Escherichia coli
- Creators
- Margaret A Davis - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Katherine N. K Baker - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Lisa H Orfe - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Devendra H Shah - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Thomas E Besser - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Douglas R Call - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.54(6), pp.2666-2669
- Academic Unit
- Paul G. Allen School for Global Animal Health; Department of Veterinary Microbiology and Pathology
- Publisher
- American Society for Microbiology (ASM)
- Number of pages
- 4
- Identifiers
- 99900547899101842
- Language
- English
- Resource Type
- Journal article