Dissecting the Regulatory Circuitry of a Eukaryotic Genome

Frank C.P Holstege; Ezra G Jennings; John J Wyrick; Tong Ihn Lee; Christoph J Hengartner; Michael R Green; Todd R Golub; Eric S Lander; Richard A Young

doi:10.1016/S0092-8674(00)81641-4

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Dissecting the Regulatory Circuitry of a Eukaryotic Genome

Journal article

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Dissecting the Regulatory Circuitry of a Eukaryotic Genome

Frank C.P Holstege, Ezra G Jennings, John J Wyrick, Tong Ihn Lee, Christoph J Hengartner, Michael R Green, Todd R Golub, Eric S Lander and Richard A Young

Cell (Cambridge), Vol.95(5), pp.717-728

1998

DOI: https://doi.org/10.1016/S0092-8674(00)81641-4

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https://hdl.handle.net/2376/106396

PMID: 9845373

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Abstract

Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.

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Title: Dissecting the Regulatory Circuitry of a Eukaryotic Genome
Creators: Frank C.P Holstege - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Ezra G Jennings - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
John J Wyrick - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Tong Ihn Lee - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Christoph J Hengartner - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Michael R Green - Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
Todd R Golub - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Eric S Lander - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Richard A Young - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Publication Details: Cell (Cambridge), Vol.95(5), pp.717-728
Academic Unit: Molecular Biosciences, School of
Publisher: Elsevier Inc
Identifiers: 99900546849401842
Language: English
Resource Type: Journal article