Journal article
Dissociation of hyperalgesia from fever following intracerebroventricular administration of interleukin-1β in the rat
Brain research, Vol.1022(1), pp.96-100
2004
Handle:
https://hdl.handle.net/2376/115544
PMID: 15353218
Abstract
Interleukin-1β (IL-1β) is a cytokine that contributes to the hyperalgesia, inactivity, and fever associated with illness. These three components of the illness response occur simultaneously following peripheral administration of IL-1β. The objective of the present study was to determine whether hyperalgesia, inactivity, and fever correspond following central administration. Rats were injected with IL-1β (0.05 pg–50 ng/10 μl) into the lateral ventricle and core body temperature and activity were assessed for 5.5 h using radio telemetry while rats remained in their home cage. Rats were removed from the cage periodically to assess nociception by measuring the latency for hindpaw withdrawal to radiant heat. The two highest doses of IL-1β (5 and 50 ng) caused an increase in core body temperature and a decrease in activity beginning 105 min following administration. No change in nociception was evident at any time after administration of IL-1β regardless of dose. These data indicate that the hyperalgesia associated with fever is triggered by a peripheral, not a central action of IL-1β, presumably by activation of vagal afferents.
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Details
- Title
- Dissociation of hyperalgesia from fever following intracerebroventricular administration of interleukin-1β in the rat
- Creators
- M.M Morgan - Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave. Vancouver, WA 98686, United StatesC.C Clayton - Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave. Vancouver, WA 98686, United StatesM.M Heinricher - Department of Neurosurgery, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Rd. Portland, OR 97201, United States
- Publication Details
- Brain research, Vol.1022(1), pp.96-100
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548144301842
- Language
- English
- Resource Type
- Journal article