Journal article
Diurnal variation of TNFα in the rat brain
Neuroreport, Vol.8(4), pp.915-918
03/03/1997
Handle:
https://hdl.handle.net/2376/116434
PMID: 9141064
Abstract
TUMOR necrosis factor-α (TNFα) is thought to play a physiological role in the brain. These studies were performed to determine whether a diurnal rhythm of TNFα exist in the rat brain. Samples were collected from hippocampus, hypothalamus, cerebral cortex, cerebellum, pons and midbrain at light onset and at 6 h intervals thereafter over a day. A TNFα bioassay was used to measure TNFα in each area. TNFα was highest at light onset in the hypothalamus, hippocampus and cerebral cortex. Levels at light onset were about 10-fold greater than minimal night-time levels. Changes in TNFα activity in other brain areas were also evident, but smaller. These results support the hypothesis that TNFα has physiological roles in the brain.
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Details
- Title
- Diurnal variation of TNFα in the rat brain
- Creators
- Rachael Floyd - 1Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAJames Krueger
- Publication Details
- Neuroreport, Vol.8(4), pp.915-918
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Lippincott-Raven Publishers
- Identifiers
- 99900547776401842
- Language
- English
- Resource Type
- Journal article