Journal article
Diurnal variations of interleukin-1 β mRNA and β-actin mRNA in rat brain
Journal of neuroimmunology, Vol.75(1), pp.69-74
1997
Handle:
https://hdl.handle.net/2376/114623
PMID: 9143239
Abstract
Interleukin-1
β (IL-1
β) is posited to play an important physiological role in brain functions in addition to its better defined role in pathology. The experiments described herein were performed to determine if IL-1
β mRNA and
β-actin display diurnal rhythms in various areas of brain. Rats were sacrificed at 4 h intervals across a 12:12 h light/dark cycle. Hypothalamic, hippocampal and cortical IL-1
β mRNA peaked just after lights were turned on, declined slightly during the remaining light period and stayed low in the dark. There were no significant changes in IL-1
β mRNA in brain stem or cerebellum samples.
β-actin mRNA levels were relatively constant across the day in the hypothalamus, brain stem and cerebellum. However,
β-actin mRNA levels were lower during the day than during the night in the hippocampus and cortex.
Metrics
8 Record Views
Details
- Title
- Diurnal variations of interleukin-1 β mRNA and β-actin mRNA in rat brain
- Creators
- Ping Taishi - Department of Physiology and Biophysics, The University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USASebastian Bredow - Department of Physiology and Biophysics, The University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USANandita Guha-Thakurta - Department of Physiology and Biophysics, The University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAFerenc Obál - Department of Physiology and Biophysics, The University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAJames M Krueger - Department of Physiology and Biophysics, The University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA
- Publication Details
- Journal of neuroimmunology, Vol.75(1), pp.69-74
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548399301842
- Language
- English
- Resource Type
- Journal article