Journal article
Do inhalation general anesthetic drugs induce the neuronal release of endogenous opioid peptides?
Life sciences (1973), Vol.77(21), pp.2603-2610
2005
Handle:
https://hdl.handle.net/2376/110673
PMID: 15978627
Abstract
The antagonism of some effects of inhalation general anesthetic agents by naloxone suggests that there may be an opioid component to anesthetic action. There is evidence that this opioid action component is due to neuronal release of endogenous opioid peptides. The strongest evidence is provided by studies that monitor changes in the concentration of opioid peptides in the perfused brain following inhalation of the anesthetic. Indirect or circumstantial evidence also comes from studies of anesthetic effects on regional brain levels of opioid peptides, antagonism of selected anesthetic effects by antisera to opioid peptides and anesthetic-induced changes radioligand binding to opioid receptors. It is likely that some inhalation general anesthetics (e.g., nitrous oxide) can induce neuronal release of opioid peptides and that this may contribute to certain components of general anesthesia (e.g., analgesia). More definitive studies utilizing in vivo microdialysis or autoradiography in selected areas of the brain during induction and successive states of general anesthesia have yet to be conducted.
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Details
- Title
- Do inhalation general anesthetic drugs induce the neuronal release of endogenous opioid peptides?
- Creators
- Raymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164, United StatesLinda K Vaughn - Department of Biomedical Sciences, School of Health Sciences, Marquette University, Milwaukee, WI 53233, USA
- Publication Details
- Life sciences (1973), Vol.77(21), pp.2603-2610
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547258201842
- Language
- English
- Resource Type
- Journal article