Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic

Karen A Wendel; Anne M Rompalo; Emily J Erbelding; T-H Chang; John F Alderete

doi:10.1086/341832

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Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic

Journal article

Open access

Peer reviewed

Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic

Karen A Wendel, Anne M Rompalo, Emily J Erbelding, T-H Chang and John F Alderete

The Journal of infectious diseases, Vol.186(4), pp.558-561

08/15/2002

DOI: https://doi.org/10.1086/341832

Handle:

https://hdl.handle.net/2376/116317

PMID: 12195385

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Abstract

Trichomonas Infections - physiopathology

Trichomonas vaginalis - pathogenicity

RNA, Double-Stranded - isolation & purification

RNA Viruses - isolation & purification

Prevalence

Cross-Sectional Studies

Humans

Virulence

RNA Viruses - genetics

Male

Sexually Transmitted Diseases - epidemiology

Sexually Transmitted Diseases - prevention & control

Ambulatory Care

Animals

Trichomonas Infections - epidemiology

Trichomonas Infections - parasitology

Adult

Female

Trichomonas vaginalis - virology

Trichomonas vaginalis (TV) can be infected with double-stranded RNA (dsRNA) viruses that may have important implications for trichomonal virulence and disease pathogenesis. A cross-sectional study was conducted in a sexually transmitted diseases clinic to determine the prevalence and clinical significance of dsRNA viral infection of TV infecting men and women. Overall, dsRNA virus was present in 21 (75%) of 28 TV isolates (95% confidence interval [CI], 55%-89%). dsRNA viral infection of TV was not associated with the presence of discharge, dysuria, genital pruritus, or genital irritation or odor. However, patients with virus-positive isolates were significantly older than patients with virus-negative isolates (median age, 38 vs. 23 years; P=.003), and virus-positive isolates were more prevalent among women (19 [86%] of 22 isolates; 95% CI, 65%-97%) than among men (2 [33%] of 6 isolates; P=.02). The age and sex specificity of virus-positive isolates may aid in understanding the differences in chronicity and clinical presentation of TV in men and women.

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Details

Title: Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic
Creators: Karen A Wendel - Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. karen-wendel@ouhsc.edu
Anne M Rompalo
Emily J Erbelding
T-H Chang
John F Alderete
Publication Details: The Journal of infectious diseases, Vol.186(4), pp.558-561
Academic Unit: Molecular Biosciences, School of
Publisher: United States
Grant note: AI-45429 / NIAID NIH HHS
Identifiers: 99900547920401842
Language: English
Resource Type: Journal article