Journal article
Dynamic Circadian Modulation in a Biomathematical Model for the Effects of Sleep and Sleep Loss on Waking Neurobehavioral Performance
Sleep (New York, N.Y.), Vol.36(12), pp.1987-1997
12/01/2013
Handle:
https://hdl.handle.net/2376/112677
PMCID: PMC3825450
PMID: 24293775
Abstract
Recent experimental observations and theoretical advances have indicated that the homeostatic equilibrium for sleep/wake regulation—and thereby sensitivity to neurobehavioral impairment from sleep loss—is modulated by prior sleep/wake history. This phenomenon was predicted by a biomathematical model developed to explain changes in neurobehavioral performance
across
days in laboratory studies of total sleep deprivation and sustained sleep restriction. The present paper focuses on the dynamics of neurobehavioral performance
within
days in this biomathematical model of fatigue. Without increasing the number of model parameters, the model was updated by incorporating time-dependence in the amplitude of the circadian modulation of performance. The updated model was calibrated using a large dataset from three laboratory experiments on psychomotor vigilance test (PVT) performance, under conditions of sleep loss and circadian misalignment; and validated using another large dataset from three different laboratory experiments. The time-dependence of circadian amplitude resulted in improved goodness-of-fit in night shift schedules, nap sleep scenarios, and recovery from prior sleep loss. The updated model predicts that the homeostatic equilibrium for sleep/wake regulation—and thus sensitivity to sleep loss—depends not only on the duration but also on the circadian timing of prior sleep. This novel theoretical insight has important implications for predicting operator alertness during work schedules involving circadian misalignment such as night shift work.
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Details
- Title
- Dynamic Circadian Modulation in a Biomathematical Model for the Effects of Sleep and Sleep Loss on Waking Neurobehavioral Performance
- Creators
- Peter McCauley - Sleep and Performance Research Center, Washington State University, Spokane, WALeonid V Kalachev - Department of Mathematical Sciences, University of Montana, Missoula, MTDaniel J Mollicone - Pulsar Informatics Inc., Philadelphia, PASiobhan Banks - Centre for Sleep Research, University of South Australia, Adelaide, AustraliaDavid F Dinges - Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PAHans P. A Van Dongen - Sleep and Performance Research Center, Washington State University, Spokane, WA
- Publication Details
- Sleep (New York, N.Y.), Vol.36(12), pp.1987-1997
- Academic Unit
- Medical Education and Clinical Science, Department of; Sleep and Performance Research Center
- Publisher
- Associated Professional Sleep Societies, LLC
- Identifiers
- 99900548353601842
- Language
- English
- Resource Type
- Journal article