Journal article
ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood–testes barrier function and testicular immune privilege
Annals of the New York Academy of Sciences, Vol.1120(1), pp.144-151
12/2007
Handle:
https://hdl.handle.net/2376/115892
PMCID: PMC2733827
PMID: 17911411
Abstract
The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as targeted deletion of the
Etv5
gene in mice (
Etv5
−/−
) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild type and
Etv5
−/−
testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition,
Etv5
−/−
recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis-barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the
Etv5
−/−
mouse.
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Details
- Title
- ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood–testes barrier function and testicular immune privilege
- Creators
- Carla M. K Morrow - Department of Veterinary Bioscience, University of Illinois at Urbana-Champaign, Urbana, IL 61802Chris E Hostetler - School of Molecular Biosciences, College of Sciences, Washington State University, Pullman, WA 99164Mike D Griswold - School of Molecular Biosciences, College of Sciences, Washington State University, Pullman, WA 99164Marie-Claude Hofmann - Department of Veterinary Bioscience, University of Illinois at Urbana-Champaign, Urbana, IL 61802Kenneth M Murphy - Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO 63110S Cooke - Department of Veterinary Bioscience, University of Illinois at Urbana-Champaign, Urbana, IL 61802Rex A Hess - Department of Veterinary Bioscience, University of Illinois at Urbana-Champaign, Urbana, IL 61802
- Publication Details
- Annals of the New York Academy of Sciences, Vol.1120(1), pp.144-151
- Academic Unit
- Molecular Biosciences, School of
- Identifiers
- 99900547598301842
- Language
- English
- Resource Type
- Journal article