Early vertebrate evolution of the TATA-binding protein, TBP

Alla A Bondareva; Edward E Schmidt

doi:10.1093/molbev/msg205

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Early vertebrate evolution of the TATA-binding protein, TBP

Journal article

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Peer reviewed

Early vertebrate evolution of the TATA-binding protein, TBP

Alla A Bondareva and Edward E Schmidt

Molecular biology and evolution, Vol.20(11), pp.1932-1939

11/2003

DOI: https://doi.org/10.1093/molbev/msg205

Handle:

https://hdl.handle.net/2376/106819

PMCID: PMC2577151

PMID: 12885957

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https://doi.org/10.1093/molbev/msg205View

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Abstract

Protein Structure, Tertiary

Amino Acid Sequence

Gene Library

Peptides - chemistry

Species Specificity

Exons

Introns

Molecular Sequence Data

Phylogeny

Animals

TATA-Box Binding Protein - genetics

Base Sequence

Fishes

Mice

Models, Genetic

DNA, Complementary - metabolism

Evolution, Molecular

TBP functions in transcription initiation in all eukaryotes and in Archaebacteria. Although the 181-amino acid (aa) carboxyl (C-) terminal core of the protein is highly conserved, TBP proteins from different phyla exhibit diverse sequences in their amino (N-) terminal region. In mice, the TBP N-terminus plays a role in protecting the placenta from maternal rejection; however the presence of similar TBP N-termini in nontherian tetrapods suggests that this domain also has more primitive functions. To gain insights into the pretherian functions of the N-terminus, we investigated its phylogenetic distribution. TBP cDNAs were isolated from representative nontetrapod jawed vertebrates (zebrafish and shark), from more primitive jawless vertebrates (lamprey and hagfish), and from a prevertebrate cephalochordate (amphioxus). Results showed that the tetrapod N-terminus likely arose coincident with the earliest vertebrates. The primary structures of vertebrate N-termini indicates that, historically, this domain has undergone events involving intragenic duplication and modification of short oligopeptide-encoding DNA sequences, which might have provided a mechanism of de novo evolution of this polypeptide.

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Title: Early vertebrate evolution of the TATA-binding protein, TBP
Creators: Alla A Bondareva - Veterinary Molecular Biology, Marsh Labs, Montana State University, USA
Edward E Schmidt
Publication Details: Molecular biology and evolution, Vol.20(11), pp.1932-1939
Academic Unit: UNKNOWN
Publisher: United States
Grant note: R01 AI055739-03 / NIAID NIH HHS R01 AI055739-02 / NIAID NIH HHS R01 AI055739-04 / NIAID NIH HHS R01 AI055739-01A1 / NIAID NIH HHS R01 AI055739 / NIAID NIH HHS R03 HD035824-02 / NICHD NIH HHS
Identifiers: 99900547070001842
Language: English
Resource Type: Journal article