Journal article
Eating the strangers within: host control of intracellular bacteria via xenophagy
Cellular microbiology, Vol.13(9), pp.1319-1327
09/2011
Handle:
https://hdl.handle.net/2376/117093
PMCID: PMC3158265
PMID: 21740500
Abstract
Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways. Recent evidence supports an increasingly important role for the autophagy pathway in innate immune defences against intracellular pathogens, as a mechanism of capture of either cytosol-adapted or vacuolar bacteria that redirect them to the lysosomal compartment for killing. Antibacterial autophagy, also referred to as xenophagy, involves selective recognition of intracellular bacteria and their targeting to the autophagic machinery for degradation. Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process.
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Details
- Title
- Eating the strangers within: host control of intracellular bacteria via xenophagy
- Creators
- Leigh A Knodler - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USAJean Celli
- Publication Details
- Cellular microbiology, Vol.13(9), pp.1319-1327
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- England
- Grant note
- Z01 AI000953-03 / Intramural NIH HHS
- Identifiers
- 99900547904301842
- Language
- English
- Resource Type
- Journal article